Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4897854..4898456 Replicon chromosome
Accession NZ_CP120549
Organism Escherichia coli strain B1172

Toxin (Protein)


Gene name higB Uniprot ID A0A366YL64
Locus tag P5710_RS23660 Protein ID WP_001519058.1
Coordinates 4898145..4898456 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P5710_RS23655 Protein ID WP_000356397.1
Coordinates 4897854..4898144 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5710_RS23630 (4893927) 4893927..4894829 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
P5710_RS23635 (4894826) 4894826..4895461 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
P5710_RS23640 (4895458) 4895458..4896387 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
P5710_RS23645 (4896603) 4896603..4896821 - 219 WP_001314326.1 CopG family transcriptional regulator -
P5710_RS23650 (4897217) 4897217..4897495 - 279 WP_001296612.1 hypothetical protein -
P5710_RS23655 (4897854) 4897854..4898144 - 291 WP_000356397.1 NadS family protein Antitoxin
P5710_RS23660 (4898145) 4898145..4898456 - 312 WP_001519058.1 hypothetical protein Toxin
P5710_RS23665 (4898685) 4898685..4899593 + 909 WP_001331553.1 alpha/beta hydrolase -
P5710_RS23670 (4899657) 4899657..4900598 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
P5710_RS23675 (4900643) 4900643..4901080 - 438 WP_000560990.1 D-aminoacyl-tRNA deacylase -
P5710_RS23680 (4901077) 4901077..4901949 - 873 WP_000920762.1 virulence factor BrkB family protein -
P5710_RS23685 (4901943) 4901943..4902542 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12202.25 Da        Isoelectric Point: 10.1861

>T275115 WP_001519058.1 NZ_CP120549:c4898456-4898145 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYKIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT275115 WP_000356397.1 NZ_CP120549:c4898144-4897854 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366YL64

Antitoxin

Source ID Structure

References