Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2619635..2620188 Replicon chromosome
Accession NZ_CP120549
Organism Escherichia coli strain B1172

Toxin (Protein)


Gene name higB Uniprot ID A0A0G9FUJ7
Locus tag P5710_RS12555 Protein ID WP_000605680.1
Coordinates 2619635..2619904 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag P5710_RS12560 Protein ID WP_000781370.1
Coordinates 2619904..2620188 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5710_RS12530 (2615221) 2615221..2615652 - 432 WP_000152305.1 peroxiredoxin OsmC -
P5710_RS12535 (2615997) 2615997..2616212 + 216 WP_000495766.1 biofilm-dependent modulation protein -
P5710_RS12540 (2616314) 2616314..2616451 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
P5710_RS12545 (2616608) 2616608..2618305 + 1698 WP_000433464.1 malate dehydrogenase -
P5710_RS12550 (2618439) 2618439..2619449 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
P5710_RS12555 (2619635) 2619635..2619904 + 270 WP_000605680.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P5710_RS12560 (2619904) 2619904..2620188 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
P5710_RS12565 (2620417) 2620417..2621070 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
P5710_RS12570 (2621063) 2621063..2621947 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
P5710_RS12575 (2621960) 2621960..2625007 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-89)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10181.73 Da        Isoelectric Point: 6.8582

>T275107 WP_000605680.1 NZ_CP120549:2619635-2619904 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVNGDA
YILDYEDYH

Download         Length: 270 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT275107 WP_000781370.1 NZ_CP120549:2619904-2620188 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G9FUJ7

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References