Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 601974..602773 Replicon chromosome
Accession NZ_CP120549
Organism Escherichia coli strain B1172

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag P5710_RS02945 Protein ID WP_000347251.1
Coordinates 601974..602438 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag P5710_RS02950 Protein ID WP_001296435.1
Coordinates 602438..602773 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5710_RS02915 (596975) 596975..597409 - 435 WP_000948834.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
P5710_RS02920 (597427) 597427..598305 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
P5710_RS02925 (598295) 598295..599074 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
P5710_RS02930 (599085) 599085..599558 - 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
P5710_RS02935 (599581) 599581..600861 - 1281 WP_000681930.1 tagatose-bisphosphate aldolase subunit KbaZ -
P5710_RS02940 (601110) 601110..601919 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
P5710_RS02945 (601974) 601974..602438 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
P5710_RS02950 (602438) 602438..602773 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
P5710_RS02955 (602922) 602922..604493 - 1572 WP_001273939.1 galactarate dehydratase -
P5710_RS02960 (604868) 604868..606202 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
P5710_RS02965 (606218) 606218..606988 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T275096 WP_000347251.1 NZ_CP120549:c602438-601974 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT275096 WP_001296435.1 NZ_CP120549:c602773-602438 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References