Detailed information of TA system TA027501

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5203871..5204283
• Replicon: chromosome
• Accession: NC_017646
• Organism: Escherichia coli O7:K1 str. CE10

Toxin (Protein)

• Gene name: symE
• Uniprot ID: B7NVB3
• Locus tag: CE10_RS26210
• Protein ID: WP_000132602.1
• Coordinates: 5203871..5204212 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5204207..5204283 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CE10_RS26195	5198937..5200217	-	1281	WP_015674821.1	DUF445 domain-containing protein	-
CE10_RS26200	5200402..5201322	+	921	WP_000181197.1	Rpn family recombination-promoting nuclease/putative transposase	-
CE10_RS29840	5201550..5201630	+	81	WP_020233658.1	hypothetical protein	-
CE10_RS30710	5201728..5203824	+	2097	WP_000648247.1	DUF262 domain-containing protein	-
CE10_RS26210	5203871..5204212	-	342	WP_000132602.1	endoribonuclease SymE	Toxin
-	5204207..5204283	+	77	NuclAT_24	-	Antitoxin
-	5204207..5204283	+	77	NuclAT_24	-	Antitoxin
-	5204207..5204283	+	77	NuclAT_24	-	Antitoxin
-	5204207..5204283	+	77	NuclAT_24	-	Antitoxin
-	5204207..5204283	+	77	NuclAT_25	-	Antitoxin
-	5204207..5204283	+	77	NuclAT_25	-	Antitoxin
-	5204207..5204283	+	77	NuclAT_25	-	Antitoxin
-	5204207..5204283	+	77	NuclAT_25	-	Antitoxin
CE10_RS26215	5204433..5206193	-	1761	WP_000110093.1	restriction endonuclease subunit S	-
CE10_RS26220	5206193..5207662	-	1470	WP_001387312.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12264.10 Da
• Isoelectric Point: 7.8219

>T27501 WP_000132602.1 NC_017646:c5204212-5203871 [Escherichia coli O7:K1 str. CE10]
MTDTHSIAQPFEAEVSPANNRQLTVSYAGRYPDYSRIPAITLKGQWLEVAGFATGTAVDVKVMEGCIVLTAQPPAAEEGE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T27501 NC_017646:c5204212-5203871 [Escherichia coli O7:K1 str. CE10]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGGGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGTCGCCGGTTTTGCTA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCCCCCGCCGCCGAAGAGGGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAAAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT27501 NC_017646:5204207-5204283 [Escherichia coli O7:K1 str. CE10]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A6C9JIC8

Antitoxin