Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4637996..4638750 | Replicon | chromosome |
| Accession | NZ_CP120394 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CI | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q8Z2U0 |
| Locus tag | PVA73_RS22920 | Protein ID | WP_000558160.1 |
| Coordinates | 4637996..4638307 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | PVA73_RS22925 | Protein ID | WP_001259009.1 |
| Coordinates | 4638304..4638750 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PVA73_RS22890 (PVA73_22885) | 4633662..4634564 | + | 903 | WP_000331359.1 | formate dehydrogenase subunit beta | - |
| PVA73_RS22895 (PVA73_22890) | 4634561..4635196 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| PVA73_RS22900 (PVA73_22895) | 4635193..4636122 | + | 930 | WP_000027727.1 | formate dehydrogenase accessory protein FdhE | - |
| PVA73_RS22905 (PVA73_22900) | 4636160..4636534 | - | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | - |
| PVA73_RS22910 (PVA73_22905) | 4636534..4636776 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| PVA73_RS22915 (PVA73_22910) | 4636981..4637910 | + | 930 | WP_001162859.1 | alpha/beta hydrolase | - |
| PVA73_RS22920 (PVA73_22915) | 4637996..4638307 | + | 312 | WP_000558160.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| PVA73_RS22925 (PVA73_22920) | 4638304..4638750 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| PVA73_RS22930 (PVA73_22925) | 4638765..4639706 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| PVA73_RS22935 (PVA73_22930) | 4639751..4640188 | - | 438 | WP_000560975.1 | D-aminoacyl-tRNA deacylase | - |
| PVA73_RS22940 (PVA73_22935) | 4640185..4641057 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| PVA73_RS22945 (PVA73_22940) | 4641051..4641650 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| PVA73_RS22950 (PVA73_22945) | 4641841..4642644 | - | 804 | WP_000059689.1 | DeoR family transcriptional regulator | - |
| PVA73_RS22955 (PVA73_22950) | 4642678..4643574 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12449.38 Da Isoelectric Point: 8.4020
>T274987 WP_000558160.1 NZ_CP120394:4637996-4638307 [Salmonella enterica subsp. enterica serovar Typhi]
VHVISRKLFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
VHVISRKLFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
Download Length: 312 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT274987 WP_001259009.1 NZ_CP120394:4638304-4638750 [Salmonella enterica subsp. enterica serovar Typhi]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|