Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3623164..3623857 Replicon chromosome
Accession NC_017646
Organism Escherichia coli O7:K1 str. CE10

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag CE10_RS18405 Protein ID WP_000415585.1
Coordinates 3623561..3623857 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag CE10_RS18400 Protein ID WP_000650107.1
Coordinates 3623164..3623559 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CE10_RS18390 3619028..3621286 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
CE10_RS18395 3621424..3623031 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
CE10_RS18400 3623164..3623559 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
CE10_RS18405 3623561..3623857 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
CE10_RS18410 3624062..3624544 - 483 WP_000183514.1 GyrI-like domain-containing protein -
CE10_RS18415 3624597..3624989 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
CE10_RS18420 3625141..3625800 + 660 WP_001221493.1 two-component system response regulator QseB -
CE10_RS18425 3625797..3627146 + 1350 WP_000673356.1 two-component system sensor histidine kinase QseC -
CE10_RS18430 3627192..3627524 - 333 WP_000914692.1 DUF2645 family protein -
CE10_RS30235 3627531..3628723 - 1193 Protein_3499 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T27495 WP_000415585.1 NC_017646:c3623857-3623561 [Escherichia coli O7:K1 str. CE10]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T27495 NC_017646:c3623857-3623561 [Escherichia coli O7:K1 str. CE10]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT27495 WP_000650107.1 NC_017646:c3623559-3623164 [Escherichia coli O7:K1 str. CE10]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT27495 NC_017646:c3623559-3623164 [Escherichia coli O7:K1 str. CE10]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References