Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3421333..3421951 Replicon chromosome
Accession NZ_CP120365
Organism Sinorhizobium kummerowiae strain CCBAU 71714

Toxin (Protein)


Gene name higB Uniprot ID H0FWR0
Locus tag PZL22_RS23340 Protein ID WP_003527306.1
Coordinates 3421655..3421951 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PZL22_RS23335 Protein ID WP_003527307.1
Coordinates 3421333..3421641 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZL22_RS23290 (PZL22_004662) 3416411..3416731 - 321 WP_003527320.1 YnfA family protein -
PZL22_RS23295 (PZL22_004663) 3416806..3416979 - 174 WP_003527319.1 hypothetical protein -
PZL22_RS23300 (PZL22_004664) 3416993..3417166 - 174 WP_003527318.1 hypothetical protein -
PZL22_RS23305 (PZL22_004665) 3417402..3418103 + 702 WP_003527316.1 glutathione S-transferase N-terminal domain-containing protein -
PZL22_RS23310 (PZL22_004666) 3418327..3418668 - 342 WP_003527314.1 DUF2147 domain-containing protein -
PZL22_RS23315 (PZL22_004667) 3419254..3419520 + 267 WP_003527312.1 sel1 repeat family protein -
PZL22_RS23320 (PZL22_004668) 3419542..3420663 - 1122 WP_003527310.1 pyridoxal phosphate-dependent aminotransferase -
PZL22_RS23330 (PZL22_004670) 3421091..3421324 - 234 WP_003527308.1 hypothetical protein -
PZL22_RS23335 (PZL22_004671) 3421333..3421641 - 309 WP_003527307.1 HigA family addiction module antitoxin Antitoxin
PZL22_RS23340 (PZL22_004672) 3421655..3421951 - 297 WP_003527306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PZL22_RS23345 (PZL22_004673) 3421999..3422304 - 306 WP_003527305.1 hypothetical protein -
PZL22_RS23350 (PZL22_004674) 3422632..3423669 + 1038 WP_003527304.1 porin -
PZL22_RS23355 (PZL22_004675) 3423778..3424710 - 933 WP_003527303.1 site-specific integrase -
PZL22_RS23360 (PZL22_004676) 3424885..3425934 - 1050 WP_003527302.1 porin -
PZL22_RS23365 (PZL22_004677) 3426148..3426636 - 489 WP_013844230.1 BA14K family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11601.01 Da        Isoelectric Point: 6.7262

>T274915 WP_003527306.1 NZ_CP120365:c3421951-3421655 [Sinorhizobium kummerowiae]
VIVGFRDDWLRTFFVDDVRSRNIPSDLEARLFRKLQMIDDAATDQDLRVPPSNHFEKLRGNLAGLHSIRVNQQWRLIFRW
DGTRGEADGIYLDDHSYR

Download         Length: 297 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11602.47 Da        Isoelectric Point: 11.0603

>AT274915 WP_003527307.1 NZ_CP120365:c3421641-3421333 [Sinorhizobium kummerowiae]
MLTTKRKPATVGEILTEEFMRPMGLTQGALAEAMGVQRKHVNELCGNRRNLTAATALILARVFGNSPDFWLNVQRRNDLW
LVMNTPKERERIERARPLENAA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0FWR0

Antitoxin

Source ID Structure

References