Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3256514..3257079 Replicon chromosome
Accession NZ_CP120359
Organism Pseudomonas sp. AA-38

Toxin (Protein)


Gene name higB Uniprot ID A0A9E8XVR8
Locus tag PVE35_RS14950 Protein ID WP_037002684.1
Coordinates 3256514..3256792 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PVE35_RS14955 Protein ID WP_268182864.1
Coordinates 3256792..3257079 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVE35_RS14920 3252016..3252837 - 822 WP_277372252.1 ABC transporter substrate-binding protein -
PVE35_RS14925 3252941..3253837 + 897 WP_277372253.1 homocysteine S-methyltransferase family protein -
PVE35_RS14930 3253891..3254295 + 405 WP_268182871.1 GNAT family N-acetyltransferase -
PVE35_RS14935 3254427..3255464 + 1038 WP_277372254.1 GGDEF domain-containing protein -
PVE35_RS14940 3255461..3255784 - 324 WP_277372255.1 hypothetical protein -
PVE35_RS14945 3255994..3256260 + 267 WP_268182866.1 hypothetical protein -
PVE35_RS14950 3256514..3256792 + 279 WP_037002684.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PVE35_RS14955 3256792..3257079 + 288 WP_268182864.1 HigA family addiction module antitoxin Antitoxin
PVE35_RS14960 3257473..3257643 + 171 WP_268182863.1 YhfG family protein -
PVE35_RS14970 3258108..3258944 - 837 WP_277372256.1 S1-like domain-containing RNA-binding protein -
PVE35_RS14975 3259174..3259365 + 192 WP_268182859.1 hypothetical protein -
PVE35_RS14980 3259413..3260507 - 1095 WP_277374890.1 PQQ-dependent sugar dehydrogenase -
PVE35_RS14985 3260633..3261358 - 726 WP_277372257.1 transporter substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10657.25 Da        Isoelectric Point: 9.5915

>T274893 WP_037002684.1 NZ_CP120359:3256514-3256792 [Pseudomonas sp. AA-38]
MIKSFQHKGLRKLFETGSTAGVQPAHAKRLRMQLAALDTAMTVDDMDIPGFRLHPLKGEMRGRWSIMVNGNWRLTFEFRD
GNAYVLDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10597.15 Da        Isoelectric Point: 7.3181

>AT274893 WP_268182864.1 NZ_CP120359:3256792-3257079 [Pseudomonas sp. AA-38]
MNMHNPPHPGEFITDIYLEPNGISGRELAEKLRVAPSTLSRVLKGTSRVTPEMALRLSVALGRSPESWLAMQDAYDLWNA
RQHVDLQQVGKLAFA

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References