Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4665921..4666523 Replicon chromosome
Accession NZ_CP120339
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_5_2021

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P1826_RS22845 Protein ID WP_001159630.1
Coordinates 4666212..4666523 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1826_RS22840 Protein ID WP_000362050.1
Coordinates 4665921..4666211 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1826_RS22825 (4663414) 4663414..4664316 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P1826_RS22830 (4664313) 4664313..4664948 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P1826_RS22835 (4664945) 4664945..4665874 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P1826_RS22840 (4665921) 4665921..4666211 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P1826_RS22845 (4666212) 4666212..4666523 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P1826_RS22850 (4666741) 4666741..4667670 + 930 WP_021294279.1 alpha/beta hydrolase -
P1826_RS22855 (4667756) 4667756..4668067 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P1826_RS22860 (4668064) 4668064..4668510 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
P1826_RS22865 (4668525) 4668525..4669466 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P1826_RS22870 (4669511) 4669511..4669948 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
P1826_RS22875 (4669945) 4669945..4670817 - 873 WP_000921423.1 virulence factor BrkB family protein -
P1826_RS22880 (4670811) 4670811..4671410 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T274796 WP_001159630.1 NZ_CP120339:c4666523-4666212 [Salmonella enterica subsp. enterica serovar Muenchen]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT274796 WP_000362050.1 NZ_CP120339:c4666211-4665921 [Salmonella enterica subsp. enterica serovar Muenchen]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References