Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4665908..4666510 Replicon chromosome
Accession NZ_CP120337
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_6_2021

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P1833_RS22880 Protein ID WP_001159630.1
Coordinates 4666199..4666510 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1833_RS22875 Protein ID WP_000362050.1
Coordinates 4665908..4666198 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1833_RS22860 (4663401) 4663401..4664303 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P1833_RS22865 (4664300) 4664300..4664935 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P1833_RS22870 (4664932) 4664932..4665861 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P1833_RS22875 (4665908) 4665908..4666198 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P1833_RS22880 (4666199) 4666199..4666510 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P1833_RS22885 (4666728) 4666728..4667657 + 930 WP_021294279.1 alpha/beta hydrolase -
P1833_RS22890 (4667743) 4667743..4668054 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P1833_RS22895 (4668051) 4668051..4668497 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
P1833_RS22900 (4668512) 4668512..4669453 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P1833_RS22905 (4669498) 4669498..4669935 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
P1833_RS22910 (4669932) 4669932..4670804 - 873 WP_000921423.1 virulence factor BrkB family protein -
P1833_RS22915 (4670798) 4670798..4671397 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T274779 WP_001159630.1 NZ_CP120337:c4666510-4666199 [Salmonella enterica subsp. enterica serovar Muenchen]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT274779 WP_000362050.1 NZ_CP120337:c4666198-4665908 [Salmonella enterica subsp. enterica serovar Muenchen]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References