Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4665749..4666351 Replicon chromosome
Accession NZ_CP120335
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_7_2021

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P1829_RS22835 Protein ID WP_001159630.1
Coordinates 4666040..4666351 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1829_RS22830 Protein ID WP_000362050.1
Coordinates 4665749..4666039 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1829_RS22815 (4663242) 4663242..4664144 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P1829_RS22820 (4664141) 4664141..4664776 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P1829_RS22825 (4664773) 4664773..4665702 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P1829_RS22830 (4665749) 4665749..4666039 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P1829_RS22835 (4666040) 4666040..4666351 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P1829_RS22840 (4666569) 4666569..4667498 + 930 WP_021294279.1 alpha/beta hydrolase -
P1829_RS22845 (4667584) 4667584..4667895 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P1829_RS22850 (4667892) 4667892..4668338 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
P1829_RS22855 (4668353) 4668353..4669294 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P1829_RS22860 (4669339) 4669339..4669776 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
P1829_RS22865 (4669773) 4669773..4670645 - 873 WP_000921423.1 virulence factor BrkB family protein -
P1829_RS22870 (4670639) 4670639..4671238 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T274761 WP_001159630.1 NZ_CP120335:c4666351-4666040 [Salmonella enterica subsp. enterica serovar Muenchen]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT274761 WP_000362050.1 NZ_CP120335:c4666039-4665749 [Salmonella enterica subsp. enterica serovar Muenchen]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References