Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4665910..4666512 Replicon chromosome
Accession NZ_CP120331
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_9_2021

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P1832_RS22845 Protein ID WP_001159630.1
Coordinates 4666201..4666512 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1832_RS22840 Protein ID WP_000362050.1
Coordinates 4665910..4666200 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1832_RS22825 (4663403) 4663403..4664305 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P1832_RS22830 (4664302) 4664302..4664937 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P1832_RS22835 (4664934) 4664934..4665863 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P1832_RS22840 (4665910) 4665910..4666200 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P1832_RS22845 (4666201) 4666201..4666512 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P1832_RS22850 (4666730) 4666730..4667659 + 930 WP_021294279.1 alpha/beta hydrolase -
P1832_RS22855 (4667745) 4667745..4668056 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P1832_RS22860 (4668053) 4668053..4668499 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
P1832_RS22865 (4668514) 4668514..4669455 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P1832_RS22870 (4669500) 4669500..4669937 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
P1832_RS22875 (4669934) 4669934..4670806 - 873 WP_000921423.1 virulence factor BrkB family protein -
P1832_RS22880 (4670800) 4670800..4671399 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T274725 WP_001159630.1 NZ_CP120331:c4666512-4666201 [Salmonella enterica subsp. enterica serovar Muenchen]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT274725 WP_000362050.1 NZ_CP120331:c4666200-4665910 [Salmonella enterica subsp. enterica serovar Muenchen]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References