Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 223494..224096 Replicon chromosome
Accession NZ_CP120322
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_1_2022

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag P1705_RS01170 Protein ID WP_001159635.1
Coordinates 223494..223805 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1705_RS01175 Protein ID WP_000362050.1
Coordinates 223806..224096 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1705_RS01135 (218607) 218607..219206 + 600 WP_000965695.1 glucose-1-phosphatase -
P1705_RS01140 (219200) 219200..220072 + 873 WP_000921423.1 virulence factor BrkB family protein -
P1705_RS01145 (220069) 220069..220506 + 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
P1705_RS01150 (220551) 220551..221492 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P1705_RS01155 (221507) 221507..221953 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
P1705_RS01160 (221950) 221950..222261 - 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
P1705_RS01165 (222347) 222347..223276 - 930 WP_001127705.1 alpha/beta hydrolase -
P1705_RS01170 (223494) 223494..223805 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P1705_RS01175 (223806) 223806..224096 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P1705_RS01180 (224143) 224143..225072 - 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
P1705_RS01185 (225069) 225069..225704 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P1705_RS01190 (225701) 225701..226603 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T274643 WP_001159635.1 NZ_CP120322:223494-223805 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT274643 WP_000362050.1 NZ_CP120322:223806-224096 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References