Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4693996..4694598 Replicon chromosome
Accession NZ_CP119980
Organism Salmonella enterica strain CRIN525628

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P2V98_RS22790 Protein ID WP_001159630.1
Coordinates 4693996..4694307 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P2V98_RS22795 Protein ID WP_000362050.1
Coordinates 4694308..4694598 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2V98_RS22755 (4689109) 4689109..4689708 + 600 WP_000965698.1 glucose-1-phosphatase -
P2V98_RS22760 (4689702) 4689702..4690574 + 873 WP_000921423.1 virulence factor BrkB family protein -
P2V98_RS22765 (4690571) 4690571..4691008 + 438 WP_023993693.1 D-aminoacyl-tRNA deacylase -
P2V98_RS22770 (4691053) 4691053..4691994 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P2V98_RS22775 (4692009) 4692009..4692455 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
P2V98_RS22780 (4692452) 4692452..4692763 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P2V98_RS22785 (4692849) 4692849..4693778 - 930 WP_021294279.1 alpha/beta hydrolase -
P2V98_RS22790 (4693996) 4693996..4694307 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P2V98_RS22795 (4694308) 4694308..4694598 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P2V98_RS22800 (4694645) 4694645..4695574 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P2V98_RS22805 (4695571) 4695571..4696206 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P2V98_RS22810 (4696203) 4696203..4697105 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T274505 WP_001159630.1 NZ_CP119980:4693996-4694307 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT274505 WP_000362050.1 NZ_CP119980:4694308-4694598 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References