Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_31
Location 1475212..1475813 Replicon chromosome
Accession NZ_CP119869
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P3C36_RS06940 Protein ID WP_003615898.1
Coordinates 1475490..1475813 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1A6FQK6
Locus tag P3C36_RS06935 Protein ID WP_003615896.1
Coordinates 1475212..1475493 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3C36_RS06900 1470248..1470625 - 378 WP_003613712.1 transposase -
P3C36_RS06905 1471213..1471575 + 363 WP_051418692.1 transposase -
P3C36_RS06910 1471572..1471919 + 348 WP_024749862.1 IS66 family insertion sequence element accessory protein TnpB -
P3C36_RS06915 1471988..1473598 + 1611 WP_003616133.1 IS66 family transposase -
P3C36_RS06920 1473601..1473834 + 234 WP_003616132.1 hypothetical protein -
P3C36_RS06925 1473871..1474216 + 346 Protein_1352 IS21 family transposase -
P3C36_RS06930 1474149..1474877 + 729 WP_024749851.1 IS21-like element helper ATPase IstB -
P3C36_RS06935 1475212..1475493 - 282 WP_003615896.1 helix-turn-helix transcriptional regulator Antitoxin
P3C36_RS06940 1475490..1475813 - 324 WP_003615898.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P3C36_RS06945 1476145..1477503 + 1359 WP_283471814.1 SNF2-related protein -
P3C36_RS06950 1477503..1478993 + 1491 WP_283471816.1 helicase-related protein -
P3C36_RS06955 1479067..1479348 - 282 Protein_1358 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1474149..1478993 4844


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12084.25 Da        Isoelectric Point: 10.8882

>T274478 WP_003615898.1 NZ_CP119869:c1475813-1475490 [Methylosinus trichosporium OB3b]
MAWRVEILNETVVAEIAALPADMQARFLRLAERINSAGLESLSEPHVKHLEGKLWELRLTGRDGIARALYVTTVGRKVVV
LRAFVKKTQKTPRAEIELALRRAKEVI

Download         Length: 324 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10063.67 Da        Isoelectric Point: 10.5567

>AT274478 WP_003615896.1 NZ_CP119869:c1475493-1475212 [Methylosinus trichosporium OB3b]
MTIPFEKIKARLMTNPAVKAEYDALAPEFEISAELVKARLRAGLSQAELATRMGTSQSAIARLESGQTLPSTKTLLRFAE
ATGSKFHVRLSAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1A6FQK6

References