Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2473947..2474509 Replicon chromosome
Accession NZ_CP119862
Organism Citrobacter sp. S171

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P2W74_RS12065 Protein ID WP_276295183.1
Coordinates 2474228..2474509 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P2W74_RS12060 Protein ID WP_276291761.1
Coordinates 2473947..2474231 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2W74_RS12045 (2471873) 2471873..2472757 + 885 WP_192612223.1 formate dehydrogenase N subunit beta -
P2W74_RS12050 (2472750) 2472750..2473403 + 654 WP_162382270.1 formate dehydrogenase-N subunit gamma -
P2W74_RS12055 (2473476) 2473476..2473946 + 471 WP_276291760.1 NUDIX domain-containing protein -
P2W74_RS12060 (2473947) 2473947..2474231 - 285 WP_276291761.1 HigA family addiction module antitoxin Antitoxin
P2W74_RS12065 (2474228) 2474228..2474509 - 282 WP_276295183.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P2W74_RS12070 (2474695) 2474695..2475705 - 1011 WP_276291762.1 alcohol dehydrogenase AdhP -
P2W74_RS12075 (2475944) 2475944..2477662 - 1719 WP_276291763.1 ABC-F family ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10670.17 Da        Isoelectric Point: 7.4728

>T274465 WP_276295183.1 NZ_CP119862:c2474509-2474228 [Citrobacter sp. S171]
MIMSFRHKGLRDLFLHGRTSGVLATQVKRLRHRLAVIDAACHINDIDMPGYRLHPLSGDRDGVWAISVSGNWRITFEFVN
GDAYLLDYEDYHA

Download         Length: 282 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10324.00 Da        Isoelectric Point: 8.8776

>AT274465 WP_276291761.1 NZ_CP119862:c2474231-2473947 [Citrobacter sp. S171]
MKMANHPRPGDIIQEALNELNVSLREFARAMDIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQTAWSLTEAE
KTVDISRLRHLAAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References