Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 39579..40229 Replicon chromosome
Accession NZ_CP119862
Organism Citrobacter sp. S171

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P2W74_RS00190 Protein ID WP_276293437.1
Coordinates 39579..39920 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P2W74_RS00195 Protein ID WP_276293438.1
Coordinates 39930..40229 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2W74_RS00175 (35512) 35512..37287 - 1776 WP_276293434.1 adenine deaminase -
P2W74_RS00180 (37464) 37464..38798 + 1335 WP_276293435.1 NCS2 family permease -
P2W74_RS00185 (38851) 38851..39303 + 453 WP_276293436.1 DUF1198 domain-containing protein -
P2W74_RS00190 (39579) 39579..39920 + 342 WP_276293437.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P2W74_RS00195 (39930) 39930..40229 + 300 WP_276293438.1 helix-turn-helix transcriptional regulator Antitoxin
P2W74_RS00200 (40350) 40350..41546 + 1197 WP_276293439.1 purine ribonucleoside efflux pump NepI -
P2W74_RS00205 (41600) 41600..42916 - 1317 WP_276293440.1 MFS transporter -
P2W74_RS00210 (42981) 42981..43838 - 858 WP_276293441.1 arabinose operon transcriptional regulator AraC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-83)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13072.81 Da        Isoelectric Point: 5.1962

>T274461 WP_276293437.1 NZ_CP119862:39579-39920 [Citrobacter sp. S171]
MWDVETTDAFDRWFDEQTEALKEDMLAAMMILSEYGPQLGRPFADTVNDSAFSNMKELRVQHQGSPIRAFFAFDPSRHGI
VLCAGDKTGLNEKKFYKDMIKFADAEYRKHLNK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10931.78 Da        Isoelectric Point: 7.2046

>AT274461 WP_276293438.1 NZ_CP119862:39930-40229 [Citrobacter sp. S171]
MATLKELMAKQTPESQARIAEKVEEMHQAIALNMLREELNMSQAELAAAMGVKQPTIAKMEQAENDPRLSTLKRYVAALG
GELSIDVKLPTGKRVAFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References