Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4774231..4774991 Replicon chromosome
Accession NZ_CP119754
Organism Superficieibacter sp. HKU1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P0H77_RS22700 Protein ID WP_276160144.1
Coordinates 4774231..4774542 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P0H77_RS22705 Protein ID WP_276160149.1
Coordinates 4774563..4774991 (+) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0H77_RS22680 (P0H77_22685) 4769639..4771402 + 1764 WP_276160123.1 ABC transporter ATP-binding protein -
P0H77_RS22685 (P0H77_22690) 4771484..4772230 + 747 WP_276160129.1 phosphatase PAP2 family protein -
P0H77_RS22690 (P0H77_22695) 4772684..4772974 - 291 Protein_4431 transcriptional regulator -
P0H77_RS22695 (P0H77_22700) 4773230..4774138 + 909 WP_276160136.1 alpha/beta hydrolase -
P0H77_RS22700 (P0H77_22705) 4774231..4774542 + 312 WP_276160144.1 type II toxin-antitoxin system HigB family toxin Toxin
P0H77_RS22705 (P0H77_22710) 4774563..4774991 + 429 WP_276160149.1 helix-turn-helix domain-containing protein Antitoxin
P0H77_RS22710 (P0H77_22715) 4775002..4775943 - 942 WP_276165204.1 fatty acid biosynthesis protein FabY -
P0H77_RS22715 (P0H77_22720) 4775988..4776425 - 438 WP_276160162.1 D-aminoacyl-tRNA deacylase -
P0H77_RS22720 (P0H77_22725) 4776422..4777282 - 861 WP_276160163.1 virulence factor BrkB family protein -
P0H77_RS22725 (P0H77_22730) 4777279..4777875 - 597 WP_276160164.1 glucose-1-phosphatase -
P0H77_RS22730 (P0H77_22735) 4777989..4778885 - 897 WP_276160165.1 aldose 1-epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4764228..4774991 10763


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(86-140)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12107.08 Da        Isoelectric Point: 9.8953

>T274438 WP_276160144.1 NZ_CP119754:4774231-4774542 [Superficieibacter sp. HKU1]
VHVISRKPFNEAIASFPGCAIALVDLLNVLEKKTFSDPQEMKSYLPSLDNFKYRKKWWVVDVAGNSLRLIAFMDFRLQKV
FVKHIVSHAEYDRLTKYYRSHTE

Download         Length: 312 bp

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 16028.27 Da        Isoelectric Point: 4.8332

>AT274438 WP_276160149.1 NZ_CP119754:4774563-4774991 [Superficieibacter sp. HKU1]
MDTASAEKMVNAFSKAVKPIPLMNGERNETEYRRALALIEFLIDRDDLDNPLFELLARQISDYEDQSPEFAEFNRRLEST
PPGVAMLRTLMDQYGLKAADLAQELGSKANVSNILNGRRALTVKHIKALSERFNLPAQAFIE

Download         Length: 429 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References