Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4779086..4779688 Replicon chromosome
Accession NZ_CP119746
Organism Escherichia coli strain E15

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P1J19_RS23125 Protein ID WP_001593848.1
Coordinates 4779377..4779688 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1J19_RS23120 Protein ID WP_000356397.1
Coordinates 4779086..4779376 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J19_RS23095 (4775031) 4775031..4775933 + 903 WP_169759669.1 formate dehydrogenase O subunit beta -
P1J19_RS23100 (4775930) 4775930..4776565 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
P1J19_RS23105 (4776562) 4776562..4777491 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
P1J19_RS23110 (4777821) 4777821..4778063 - 243 WP_001087409.1 protein YiiF -
P1J19_RS23115 (4778282) 4778282..4778500 - 219 WP_001295676.1 CopG family transcriptional regulator -
P1J19_RS23120 (4779086) 4779086..4779376 - 291 WP_000356397.1 NadS family protein Antitoxin
P1J19_RS23125 (4779377) 4779377..4779688 - 312 WP_001593848.1 hypothetical protein Toxin
P1J19_RS23130 (4779917) 4779917..4780810 + 894 WP_276169778.1 alpha/beta hydrolase -
P1J19_RS23135 (4780889) 4780889..4781830 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
P1J19_RS23140 (4781875) 4781875..4782312 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
P1J19_RS23145 (4782309) 4782309..4783181 - 873 WP_000920762.1 virulence factor BrkB family protein -
P1J19_RS23150 (4783175) 4783175..4783774 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12174.15 Da        Isoelectric Point: 9.7791

>T274408 WP_001593848.1 NZ_CP119746:c4779688-4779377 [Escherichia coli]
MLFIETEIFTEDVQKPLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT274408 WP_000356397.1 NZ_CP119746:c4779376-4779086 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References