Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3885058..3885599 Replicon chromosome
Accession NZ_CP119746
Organism Escherichia coli strain E15

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag P1J19_RS18935 Protein ID WP_000615982.1
Coordinates 3885321..3885599 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag P1J19_RS18930 Protein ID WP_000729704.1
Coordinates 3885058..3885318 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J19_RS18905 (3880094) 3880094..3881233 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
P1J19_RS18910 (3881217) 3881217..3883310 + 2094 WP_001140806.1 flagellar biosynthesis protein FlhA -
P1J19_RS18915 (3883415) 3883415..3883693 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
P1J19_RS18920 (3883686) 3883686..3884042 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
P1J19_RS18925 (3884099) 3884099..3884872 - 774 WP_000543899.1 C40 family peptidase -
P1J19_RS18930 (3885058) 3885058..3885318 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
P1J19_RS18935 (3885321) 3885321..3885599 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
P1J19_RS18940 (3885755) 3885755..3886495 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
P1J19_RS18945 (3886466) 3886466..3887233 - 768 WP_000333380.1 class II glutamine amidotransferase -
P1J19_RS18950 (3887439) 3887439..3888017 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T274405 WP_000615982.1 NZ_CP119746:3885321-3885599 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT274405 WP_000729704.1 NZ_CP119746:3885058-3885318 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References