Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 763610..764303 Replicon chromosome
Accession NZ_CP119734
Organism Escherichia coli strain E92

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag P1J22_RS03780 Protein ID WP_000415584.1
Coordinates 763610..763906 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag P1J22_RS03785 Protein ID WP_000650107.1
Coordinates 763908..764303 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J22_RS03750 (759285) 759285..759599 - 315 WP_000958598.1 putative quinol monooxygenase -
P1J22_RS03755 (759630) 759630..760211 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
P1J22_RS03760 (760321) 760321..761670 - 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
P1J22_RS03765 (761667) 761667..762326 - 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
P1J22_RS03770 (762478) 762478..762870 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
P1J22_RS03775 (762923) 762923..763405 + 483 WP_000183494.1 GyrI-like domain-containing protein -
P1J22_RS03780 (763610) 763610..763906 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
P1J22_RS03785 (763908) 763908..764303 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
P1J22_RS03790 (764436) 764436..766043 + 1608 WP_001324265.1 ABC transporter substrate-binding protein -
P1J22_RS03795 (766181) 766181..768439 + 2259 WP_001748758.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 751882..764303 12421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T274334 WP_000415584.1 NZ_CP119734:763610-763906 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT274334 WP_000650107.1 NZ_CP119734:763908-764303 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References