Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 641653..642452 Replicon chromosome
Accession NZ_CP119734
Organism Escherichia coli strain E92

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag P1J22_RS03185 Protein ID WP_000347251.1
Coordinates 641653..642117 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag P1J22_RS03190 Protein ID WP_001307405.1
Coordinates 642117..642452 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J22_RS03155 (636654) 636654..637088 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
P1J22_RS03160 (637106) 637106..637984 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
P1J22_RS03165 (637974) 637974..638753 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
P1J22_RS03170 (638764) 638764..639237 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
P1J22_RS03175 (639260) 639260..640540 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
P1J22_RS03180 (640789) 640789..641598 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
P1J22_RS03185 (641653) 641653..642117 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
P1J22_RS03190 (642117) 642117..642452 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
P1J22_RS03195 (642601) 642601..644172 - 1572 WP_001273761.1 galactarate dehydratase -
P1J22_RS03200 (644547) 644547..645881 + 1335 WP_000599652.1 galactarate/glucarate/glycerate transporter GarP -
P1J22_RS03205 (645897) 645897..646667 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T274333 WP_000347251.1 NZ_CP119734:c642117-641653 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp


Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT274333 WP_001307405.1 NZ_CP119734:c642452-642117 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829CJ20


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References