Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4790333..4790935 Replicon chromosome
Accession NZ_CP119730
Organism Escherichia coli strain E32

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P1J21_RS23205 Protein ID WP_001593848.1
Coordinates 4790624..4790935 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1J21_RS23200 Protein ID WP_000356397.1
Coordinates 4790333..4790623 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J21_RS23175 (4786278) 4786278..4787180 + 903 WP_169759669.1 formate dehydrogenase O subunit beta -
P1J21_RS23180 (4787177) 4787177..4787812 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
P1J21_RS23185 (4787809) 4787809..4788738 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
P1J21_RS23190 (4789068) 4789068..4789310 - 243 WP_001087409.1 protein YiiF -
P1J21_RS23195 (4789529) 4789529..4789747 - 219 WP_001295676.1 CopG family transcriptional regulator -
P1J21_RS23200 (4790333) 4790333..4790623 - 291 WP_000356397.1 NadS family protein Antitoxin
P1J21_RS23205 (4790624) 4790624..4790935 - 312 WP_001593848.1 hypothetical protein Toxin
P1J21_RS23210 (4791164) 4791164..4792057 + 894 WP_276169778.1 alpha/beta hydrolase -
P1J21_RS23215 (4792136) 4792136..4793077 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
P1J21_RS23220 (4793122) 4793122..4793559 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
P1J21_RS23225 (4793556) 4793556..4794428 - 873 WP_000920762.1 virulence factor BrkB family protein -
P1J21_RS23230 (4794422) 4794422..4795021 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12174.15 Da        Isoelectric Point: 9.7791

>T274318 WP_001593848.1 NZ_CP119730:c4790935-4790624 [Escherichia coli]
MLFIETEIFTEDVQKPLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT274318 WP_000356397.1 NZ_CP119730:c4790623-4790333 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References