Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3896305..3896846 Replicon chromosome
Accession NZ_CP119730
Organism Escherichia coli strain E32

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag P1J21_RS19015 Protein ID WP_000615982.1
Coordinates 3896568..3896846 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag P1J21_RS19010 Protein ID WP_000729704.1
Coordinates 3896305..3896565 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J21_RS18985 (3891341) 3891341..3892480 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
P1J21_RS18990 (3892464) 3892464..3894557 + 2094 WP_001140806.1 flagellar biosynthesis protein FlhA -
P1J21_RS18995 (3894662) 3894662..3894940 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
P1J21_RS19000 (3894933) 3894933..3895289 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
P1J21_RS19005 (3895346) 3895346..3896119 - 774 WP_000543899.1 C40 family peptidase -
P1J21_RS19010 (3896305) 3896305..3896565 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
P1J21_RS19015 (3896568) 3896568..3896846 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
P1J21_RS19020 (3897002) 3897002..3897742 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
P1J21_RS19025 (3897713) 3897713..3898480 - 768 WP_000333380.1 class II glutamine amidotransferase -
P1J21_RS19030 (3898686) 3898686..3899264 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T274315 WP_000615982.1 NZ_CP119730:3896568-3896846 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT274315 WP_000729704.1 NZ_CP119730:3896305-3896565 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References