Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4789557..4790159 Replicon chromosome
Accession NZ_CP119726
Organism Escherichia coli strain E16

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P1J20_RS23195 Protein ID WP_001593848.1
Coordinates 4789848..4790159 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1J20_RS23190 Protein ID WP_000356397.1
Coordinates 4789557..4789847 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J20_RS23165 (4785502) 4785502..4786404 + 903 WP_169759669.1 formate dehydrogenase O subunit beta -
P1J20_RS23170 (4786401) 4786401..4787036 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
P1J20_RS23175 (4787033) 4787033..4787962 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
P1J20_RS23180 (4788292) 4788292..4788534 - 243 WP_001087409.1 protein YiiF -
P1J20_RS23185 (4788753) 4788753..4788971 - 219 WP_001295676.1 CopG family transcriptional regulator -
P1J20_RS23190 (4789557) 4789557..4789847 - 291 WP_000356397.1 NadS family protein Antitoxin
P1J20_RS23195 (4789848) 4789848..4790159 - 312 WP_001593848.1 hypothetical protein Toxin
P1J20_RS23200 (4790388) 4790388..4791281 + 894 WP_276169778.1 alpha/beta hydrolase -
P1J20_RS23205 (4791360) 4791360..4792301 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
P1J20_RS23210 (4792346) 4792346..4792783 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
P1J20_RS23215 (4792780) 4792780..4793652 - 873 WP_000920762.1 virulence factor BrkB family protein -
P1J20_RS23220 (4793646) 4793646..4794245 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12174.15 Da        Isoelectric Point: 9.7791

>T274287 WP_001593848.1 NZ_CP119726:c4790159-4789848 [Escherichia coli]
MLFIETEIFTEDVQKPLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT274287 WP_000356397.1 NZ_CP119726:c4789847-4789557 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References