Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1100611..1101189 Replicon chromosome
Accession NZ_CP119676
Organism Varunaivibrio sulfuroxidans strain TC8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P3M64_RS05150 Protein ID WP_132940164.1
Coordinates 1100611..1100892 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag P3M64_RS05155 Protein ID WP_132940163.1
Coordinates 1100908..1101189 (+) Length 94 a.a.

Genomic Context

P3M64_RS05095P3M64_RS05105P3M64_RS05110P3M64_RS05115P3M64_RS05120P3M64_RS05125P3M64_RS05130P3M64_RS05135P3M64_RS05145P3M64_RS05150P3M64_RS05155P3M64_RS05160P3M64_RS05165P3M64_RS05180P3M64_RS05200P3M64_RS05100P3M64_RS05140P3M64_RS05170P3M64_RS05175P3M64_RS05185P3M64_RS05190P3M64_RS05195
Location: 1096820..1097248 (429 bp)
Type: Others
Protein ID: WP_132940173.1
Location: 1097594..1097857 (264 bp)
Type: Others
Protein ID: WP_165886415.1
Location: 1097989..1098267 (279 bp)
Type: Others
Protein ID: WP_243644894.1
Location: 1098267..1098590 (324 bp)
Type: Others
Protein ID: WP_132940170.1
Location: 1098744..1098932 (189 bp)
Type: Others
Protein ID: WP_132940169.1
Location: 1098938..1099342 (405 bp)
Type: Others
Protein ID: WP_132940168.1
Location: 1099436..1099728 (293 bp)
Type: Others
Protein ID: Protein_1008
Location: 1099730..1100050 (321 bp)
Type: Others
Protein ID: WP_132940167.1
Location: 1100306..1100584 (279 bp)
Type: Others
Protein ID: WP_165886414.1
Location: 1100611..1100892 (282 bp)
Type: Toxin
Protein ID: WP_132940164.1
Location: 1100908..1101189 (282 bp)
Type: Antitoxin
Protein ID: WP_132940163.1
Location: 1101233..1101508 (276 bp)
Type: Others
Protein ID: WP_132940177.1
Location: 1101468..1101758 (291 bp)
Type: Others
Protein ID: WP_132940162.1
Location: 1103334..1103558 (225 bp)
Type: Others
Protein ID: WP_132940160.1
Location: 1104964..1105263 (300 bp)
Type: Others
Protein ID: WP_132940156.1
Location: 1097316..1097552 (237 bp)
Type: Others
Protein ID: WP_132940172.1
Location: 1100028..1100264 (237 bp)
Type: Others
Protein ID: WP_132940166.1
Location: 1101782..1102996 (1215 bp)
Type: Others
Protein ID: WP_132940161.1
Location: 1102929..1103183 (255 bp)
Type: Others
Protein ID: WP_243644900.1
Location: 1103743..1104186 (444 bp)
Type: Others
Protein ID: WP_132940159.1
Location: 1104155..1104436 (282 bp)
Type: Others
Protein ID: WP_132940158.1
Location: 1104439..1104768 (330 bp)
Type: Others
Protein ID: WP_132940157.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
P3M64_RS05095 (P3M64_05095)1096820..1097248+429WP_132940173.1type II toxin-antitoxin system HicB family antitoxin-
P3M64_RS05100 (P3M64_05100)1097316..1097552-237WP_132940172.1hypothetical protein-
P3M64_RS05105 (P3M64_05105)1097594..1097857+264WP_165886415.1replication initiation protein RepC-
P3M64_RS05110 (P3M64_05110)1097989..1098267+279WP_243644894.1type II toxin-antitoxin system RelE/ParE family toxin-
P3M64_RS05115 (P3M64_05115)1098267..1098590+324WP_132940170.1HigA family addiction module antitoxin-
P3M64_RS05120 (P3M64_05120)1098744..1098932+189WP_132940169.1type II toxin-antitoxin system HicA family toxin-
P3M64_RS05125 (P3M64_05125)1098938..1099342+405WP_132940168.1type II toxin-antitoxin system HicB family antitoxin-
P3M64_RS05130 (P3M64_05130)1099436..1099728+293Protein_1008type II toxin-antitoxin system RelE/ParE family toxin-
P3M64_RS05135 (P3M64_05135)1099730..1100050+321WP_132940167.1putative addiction module antidote protein-
P3M64_RS05140 (P3M64_05140)1100028..1100264-237WP_132940166.1hypothetical protein-
P3M64_RS05145 (P3M64_05145)1100306..1100584+279WP_165886414.1replication initiation protein RepC-
P3M64_RS05150 (P3M64_05150)1100611..1100892+282WP_132940164.1type II toxin-antitoxin system RelE/ParE family toxinToxin
P3M64_RS05155 (P3M64_05155)1100908..1101189+282WP_132940163.1HigA family addiction module antitoxinAntitoxin
P3M64_RS05160 (P3M64_05160)1101233..1101508+276WP_132940177.1BrnT family toxin-
P3M64_RS05165 (P3M64_05165)1101468..1101758+291WP_132940162.1helix-turn-helix domain-containing protein-
P3M64_RS05170 (P3M64_05170)1101782..1102996-1215WP_132940161.1recombinase family protein-
P3M64_RS05175 (P3M64_05175)1102929..1103183-255WP_243644900.1BRO family protein-
P3M64_RS05180 (P3M64_05180)1103334..1103558+225WP_132940160.1hypothetical protein-
P3M64_RS05185 (P3M64_05185)1103743..1104186-444WP_132940159.1hypothetical protein-
P3M64_RS05190 (P3M64_05190)1104155..1104436-282WP_132940158.1hypothetical protein-
P3M64_RS05195 (P3M64_05195)1104439..1104768-330WP_132940157.1hypothetical protein-
P3M64_RS05200 (P3M64_05200)1104964..1105263+300WP_132940156.1helix-turn-helix transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1094065..111958925524


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11264.94 Da        Isoelectric Point: 9.4662

>T274267 WP_132940164.1 NZ_CP119676:1100611-1100892 [Varunaivibrio sulfuroxidans]
MIKSFHNKETQALFERVRCYRKWRSFERIALRKLVMVHAAKELKDLACPPNNRLEGLKGDRQSQYSIRINQQYRVCFEWK
EGDAYDVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10184.80 Da        Isoelectric Point: 10.2710

>AT274267 WP_132940163.1 NZ_CP119676:1100908-1101189 [Varunaivibrio sulfuroxidans]
MIFPIHPGEILKNEFMEPLGLSANKLAAALKVPTNRLTGIVGGDRSITADTALRLSDAFGTTPEFWVGLQNHYNLEVARQ
KKRPKIERISAAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References