Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4566875..4567477 Replicon chromosome
Accession NZ_CP119577
Organism Escherichia coli strain C012_chr

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag P1J04_RS22035 Protein ID WP_000897305.1
Coordinates 4567166..4567477 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1J04_RS22030 Protein ID WP_000356397.1
Coordinates 4566875..4567165 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J04_RS22005 (4562801) 4562801..4563703 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
P1J04_RS22010 (4563700) 4563700..4564335 + 636 WP_112039834.1 formate dehydrogenase cytochrome b556 subunit -
P1J04_RS22015 (4564332) 4564332..4565261 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
P1J04_RS22020 (4565591) 4565591..4565833 - 243 WP_001086388.1 protein YiiF -
P1J04_RS22025 (4566052) 4566052..4566270 - 219 WP_001297075.1 CopG family transcriptional regulator -
P1J04_RS22030 (4566875) 4566875..4567165 - 291 WP_000356397.1 NadS family protein Antitoxin
P1J04_RS22035 (4567166) 4567166..4567477 - 312 WP_000897305.1 hypothetical protein Toxin
P1J04_RS22040 (4567706) 4567706..4568614 + 909 WP_001162704.1 alpha/beta hydrolase -
P1J04_RS22045 (4568678) 4568678..4569619 - 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
P1J04_RS22050 (4569664) 4569664..4570101 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
P1J04_RS22055 (4570098) 4570098..4570970 - 873 WP_000920762.1 virulence factor BrkB family protein -
P1J04_RS22060 (4570964) 4570964..4571563 - 600 WP_001295269.1 glucose-1-phosphatase -
P1J04_RS22065 (4571662) 4571662..4572447 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T274242 WP_000897305.1 NZ_CP119577:c4567477-4567166 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT274242 WP_000356397.1 NZ_CP119577:c4567165-4566875 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References