Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3751433..3751974 Replicon chromosome
Accession NZ_CP119577
Organism Escherichia coli strain C012_chr

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag P1J04_RS18285 Protein ID WP_000615976.1
Coordinates 3751696..3751974 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag P1J04_RS18280 Protein ID WP_000729704.1
Coordinates 3751433..3751693 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J04_RS18255 (3747216) 3747216..3748001 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
P1J04_RS18260 (3747973) 3747973..3749685 + 1713 Protein_3569 flagellar biosynthesis protein FlhA -
P1J04_RS18265 (3749790) 3749790..3750068 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
P1J04_RS18270 (3750061) 3750061..3750417 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
P1J04_RS18275 (3750474) 3750474..3751247 - 774 WP_000543899.1 C40 family peptidase -
P1J04_RS18280 (3751433) 3751433..3751693 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
P1J04_RS18285 (3751696) 3751696..3751974 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
P1J04_RS18290 (3752130) 3752130..3752870 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
P1J04_RS18295 (3752841) 3752841..3753608 - 768 WP_000333380.1 class II glutamine amidotransferase -
P1J04_RS18300 (3753814) 3753814..3754392 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T274239 WP_000615976.1 NZ_CP119577:3751696-3751974 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT274239 WP_000729704.1 NZ_CP119577:3751433-3751693 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References