Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1770505..1771028 Replicon chromosome
Accession NZ_CP119571
Organism Staphylococcus aureus strain N08CSA36

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag PZ486_RS09115 Protein ID WP_000074043.1
Coordinates 1770505..1770771 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag PZ486_RS09120 Protein ID WP_000587618.1
Coordinates 1770771..1771028 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZ486_RS09095 (PZ486_09095) 1765811..1766998 - 1188 WP_000026194.1 MFS transporter -
PZ486_RS09100 (PZ486_09100) 1767394..1768170 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
PZ486_RS09105 (PZ486_09105) 1768163..1768825 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
PZ486_RS09110 (PZ486_09110) 1769073..1770149 - 1077 WP_001076673.1 M42 family metallopeptidase -
PZ486_RS09115 (PZ486_09115) 1770505..1770771 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
PZ486_RS09120 (PZ486_09120) 1770771..1771028 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PZ486_RS09125 (PZ486_09125) 1771387..1771842 + 456 WP_000732076.1 DUF1307 domain-containing protein -
PZ486_RS09130 (PZ486_09130) 1772010..1773587 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
PZ486_RS09135 (PZ486_09135) 1773782..1774531 + 750 WP_000072466.1 CPBP family lipoprotein N-acylation protein LnsB -
PZ486_RS09140 (PZ486_09140) 1774762..1775955 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T274218 WP_000074043.1 NZ_CP119571:c1770771-1770505 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT274218 WP_000587618.1 NZ_CP119571:c1771028-1770771 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References