Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1712218..1712735 Replicon chromosome
Accession NZ_CP119571
Organism Staphylococcus aureus strain N08CSA36

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag PZ486_RS08835 Protein ID WP_000113262.1
Coordinates 1712218..1712484 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag PZ486_RS08840 Protein ID WP_000584499.1
Coordinates 1712484..1712735 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZ486_RS08805 (PZ486_08805) 1707643..1708179 - 537 WP_031585827.1 GNAT family N-acetyltransferase -
PZ486_RS08810 (PZ486_08810) 1708412..1709236 - 825 WP_000572040.1 formate/nitrite transporter family protein -
PZ486_RS08815 (PZ486_08815) 1709453..1709635 - 183 WP_000230294.1 hypothetical protein -
PZ486_RS08820 (PZ486_08820) 1709719..1710186 - 468 WP_000153344.1 SRPBCC domain-containing protein -
PZ486_RS08825 (PZ486_08825) 1710372..1711922 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
PZ486_RS08830 (PZ486_08830) 1712106..1712183 - 78 Protein_1707 hypothetical protein -
PZ486_RS08835 (PZ486_08835) 1712218..1712484 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
PZ486_RS08840 (PZ486_08840) 1712484..1712735 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PZ486_RS08845 (PZ486_08845) 1712900..1713001 - 102 WP_031774922.1 hypothetical protein -
PZ486_RS08850 (PZ486_08850) 1713008..1713607 - 600 WP_000162813.1 DsbA family protein -
PZ486_RS08855 (PZ486_08855) 1713626..1713988 - 363 WP_000819843.1 DUF4467 domain-containing protein -
PZ486_RS08860 (PZ486_08860) 1714243..1715493 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
PZ486_RS08865 (PZ486_08865) 1715590..1716321 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
PZ486_RS08870 (PZ486_08870) 1716318..1717037 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T274216 WP_000113262.1 NZ_CP119571:c1712484-1712218 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT274216 WP_000584499.1 NZ_CP119571:c1712735-1712484 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References