Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3165430..3166007 Replicon chromosome
Accession NZ_CP119566
Organism Pararhizobium sp. T808

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PYR65_RS15435 Protein ID WP_276118596.1
Coordinates 3165729..3166007 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0Q7M364
Locus tag PYR65_RS15430 Protein ID WP_060641242.1
Coordinates 3165430..3165717 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR65_RS15405 3161161..3162006 - 846 WP_276118592.1 oxidoreductase -
PYR65_RS15410 3162091..3162435 - 345 WP_276118593.1 cupin domain-containing protein -
PYR65_RS15415 3162490..3163770 - 1281 WP_060641239.1 O-acetylhomoserine aminocarboxypropyltransferase -
PYR65_RS15420 3163902..3164330 - 429 WP_276118594.1 CoA-binding protein -
PYR65_RS15425 3164574..3165410 + 837 WP_276118595.1 EamA family transporter -
PYR65_RS15430 3165430..3165717 - 288 WP_060641242.1 HigA family addiction module antitoxin Antitoxin
PYR65_RS15435 3165729..3166007 - 279 WP_276118596.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYR65_RS15440 3166060..3166881 - 822 WP_276118597.1 enoyl-CoA hydratase -
PYR65_RS15445 3167038..3167469 + 432 WP_276118598.1 PaaI family thioesterase -
PYR65_RS15450 3167696..3168160 + 465 WP_060641245.1 50S ribosomal protein L13 -
PYR65_RS15455 3168163..3168636 + 474 WP_060641246.1 30S ribosomal protein S9 -
PYR65_RS15460 3168715..3169176 - 462 WP_060641247.1 Lrp/AsnC family transcriptional regulator -
PYR65_RS15465 3169299..3170090 + 792 WP_276118599.1 phenylalanine 4-monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10384.92 Da        Isoelectric Point: 10.0104

>T274197 WP_276118596.1 NZ_CP119566:c3166007-3165729 [Pararhizobium sp. T808]
MIKSIANTATRQFTESGKSKFSGLDAGKAKMRLVMLQNARSLDDLAPLKSVGLHKLSGDRKNQWAMTINGPWRLCFRFED
GHAYDVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10272.76 Da        Isoelectric Point: 8.7092

>AT274197 WP_060641242.1 NZ_CP119566:c3165717-3165430 [Pararhizobium sp. T808]
MFEVHPGAMLREELDARSMTGNALALALRINSGRISEILTGKRAISADTALRLGQFFGNDPQFWLGLQATYDLAVASRQN
GDRIKAEVLPAKSAA

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q7M364

References