Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1758887..1759471 Replicon chromosome
Accession NZ_CP119563
Organism Rhodobacter capsulatus strain 37b4

Toxin (Protein)


Gene name higB Uniprot ID A0A1G7QST7
Locus tag PUH89_RS08530 Protein ID WP_074555902.1
Coordinates 1759190..1759471 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A1G7QST0
Locus tag PUH89_RS08525 Protein ID WP_074555901.1
Coordinates 1758887..1759177 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUH89_RS08505 (PUH89_08505) 1754803..1756401 + 1599 WP_074555897.1 hypothetical protein -
PUH89_RS08510 (PUH89_08510) 1756435..1756677 + 243 WP_074555898.1 hypothetical protein -
PUH89_RS08515 (PUH89_08515) 1756751..1757044 + 294 WP_074555899.1 hypothetical protein -
PUH89_RS08520 (PUH89_08520) 1757461..1758552 + 1092 WP_074555900.1 hypothetical protein -
PUH89_RS08525 (PUH89_08525) 1758887..1759177 - 291 WP_074555901.1 HigA family addiction module antitoxin Antitoxin
PUH89_RS08530 (PUH89_08530) 1759190..1759471 - 282 WP_074555902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUH89_RS08535 (PUH89_08535) 1759929..1761035 + 1107 WP_201778588.1 DNA adenine methylase -
PUH89_RS08540 (PUH89_08540) 1761035..1761871 + 837 WP_055211498.1 DpnII family type II restriction endonuclease -
PUH89_RS08545 (PUH89_08545) 1761968..1762763 - 796 Protein_1684 DNA adenine methylase -
PUH89_RS08550 (PUH89_08550) 1762941..1763288 - 348 WP_276131108.1 hypothetical protein -
PUH89_RS08555 (PUH89_08555) 1763436..1764026 + 591 WP_276131099.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1753603..1763288 9685


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(20-82)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10434.80 Da        Isoelectric Point: 7.2773

>T274191 WP_074555902.1 NZ_CP119563:c1759471-1759190 [Rhodobacter capsulatus]
MIQSTKGKLATDAVNGHYGKDFPSDLVKRTRVLLSALHAASVLEDLRFPPGNNLEELKGDRAGQHSVRINRQWRICFVWT
ETGPADIEIADYQ

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10492.12 Da        Isoelectric Point: 8.6831

>AT274191 WP_074555901.1 NZ_CP119563:c1759177-1758887 [Rhodobacter capsulatus]
MITLANPSHPGAVLDELFLSALDLSAGALAKKLGVPRTRIERLVKGETALTADTALRLSGFFGNTAEFWMNLQRAYDLDR
ARKTVDVSFIQPMQAT

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G7QST7

Antitoxin

Source ID Structure
AlphaFold DB A0A1G7QST0

References