Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3145758..3146451 Replicon chromosome
Accession NC_017638
Organism Escherichia coli DH1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag ECDH1ME8569_RS15510 Protein ID WP_000415584.1
Coordinates 3146155..3146451 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag ECDH1ME8569_RS15505 Protein ID WP_000650107.1
Coordinates 3145758..3146153 (-) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECDH1ME8569_RS15495 (ECDH1ME8569_2915) 3141622..3143880 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
ECDH1ME8569_RS15500 (ECDH1ME8569_2916) 3144018..3145625 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
ECDH1ME8569_RS15505 (ECDH1ME8569_2917) 3145758..3146153 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
ECDH1ME8569_RS15510 (ECDH1ME8569_2918) 3146155..3146451 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
ECDH1ME8569_RS15515 (ECDH1ME8569_2919) 3146656..3147138 - 483 WP_000183505.1 transcriptional regulator -
ECDH1ME8569_RS15520 (ECDH1ME8569_2920) 3147191..3147583 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
ECDH1ME8569_RS15525 (ECDH1ME8569_2921) 3147735..3148394 + 660 WP_001221495.1 two-component system response regulator QseB -
ECDH1ME8569_RS15530 (ECDH1ME8569_2922) 3148391..3149740 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
ECDH1ME8569_RS15535 (ECDH1ME8569_2923) 3149786..3150118 - 333 WP_000917684.1 DUF2645 family protein -
ECDH1ME8569_RS15540 (ECDH1ME8569_2924) 3150437..3151018 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
ECDH1ME8569_RS15545 (ECDH1ME8569_2925) 3151049..3151363 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T27419 WP_000415584.1 NC_017638:c3146451-3146155 [Escherichia coli DH1]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T27419 NC_017638:c3146451-3146155 [Escherichia coli DH1]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT27419 WP_000650107.1 NC_017638:c3146153-3145758 [Escherichia coli DH1]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT27419 NC_017638:c3146153-3145758 [Escherichia coli DH1]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References