Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-YefM
Location 1663924..1664444 Replicon chromosome
Accession NZ_CP119416
Organism Agrobacterium fabrum strain A8196

Toxin (Protein)


Gene name yoeB Uniprot ID A9CID9
Locus tag P0M24_RS08345 Protein ID WP_010972002.1
Coordinates 1663924..1664193 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q7CY23
Locus tag P0M24_RS08350 Protein ID WP_010972003.1
Coordinates 1664190..1664444 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0M24_RS08325 (P0M24_08325) 1658955..1660649 - 1695 WP_010971998.1 iron ABC transporter permease -
P0M24_RS08330 (P0M24_08330) 1660659..1661642 - 984 WP_010971999.1 ABC transporter substrate-binding protein -
P0M24_RS08335 (P0M24_08335) 1661951..1663195 - 1245 WP_010972000.1 PLP-dependent aminotransferase family protein -
P0M24_RS08340 (P0M24_08340) 1663470..1663919 + 450 WP_010972001.1 RbsD/FucU family protein -
P0M24_RS08345 (P0M24_08345) 1663924..1664193 - 270 WP_010972002.1 Txe/YoeB family addiction module toxin Toxin
P0M24_RS08350 (P0M24_08350) 1664190..1664444 - 255 WP_010972003.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
P0M24_RS08355 (P0M24_08355) 1664583..1665602 - 1020 WP_010972004.1 ketol-acid reductoisomerase -
P0M24_RS08360 (P0M24_08360) 1665650..1666303 - 654 WP_006311841.1 TetR/AcrR family transcriptional regulator -
P0M24_RS08365 (P0M24_08365) 1666703..1667608 - 906 WP_010972005.1 AraC family transcriptional regulator -
P0M24_RS08370 (P0M24_08370) 1667798..1668844 + 1047 WP_006311839.1 NAD(P)-dependent alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10612.09 Da        Isoelectric Point: 9.8742

>T274136 WP_010972002.1 NZ_CP119416:c1664193-1663924 [Agrobacterium fabrum]
MKLVWTLSSWDDYEFWQRTDARMVEKINDLIRNAKRTPFAGLGKPEPLKGDMAGYWSRRITAEHRFVYRVSGSGSEQRLE
VIQCRFHYQ

Download         Length: 270 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9577.70 Da        Isoelectric Point: 4.6749

>AT274136 WP_010972003.1 NZ_CP119416:c1664444-1664190 [Agrobacterium fabrum]
MANVRFTEFRQNFATHFDRVLETRAPLLVTRQGKEAVVVLAEGEYESMQETLHLLSNPANASRLRASMGELERGDTIERD
PTEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6N90

Antitoxin

Source ID Structure
AlphaFold DB Q7CY23

References