Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 694993..695686 Replicon chromosome
Accession NZ_CP119404
Organism Escherichia coli strain MRE162 substr. UK

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PX811_RS03400 Protein ID WP_000415584.1
Coordinates 694993..695289 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PX811_RS03405 Protein ID WP_000650107.1
Coordinates 695291..695686 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX811_RS03365 (690081) 690081..690395 - 315 WP_000958598.1 putative quinol monooxygenase -
PX811_RS03370 (690426) 690426..691007 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PX811_RS03375 (691326) 691326..691658 + 333 WP_000917684.1 DUF2645 family protein -
PX811_RS03380 (691704) 691704..693053 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PX811_RS03385 (693050) 693050..693709 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PX811_RS03390 (693861) 693861..694253 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PX811_RS03395 (694306) 694306..694788 + 483 WP_000183505.1 GyrI-like domain-containing protein -
PX811_RS03400 (694993) 694993..695289 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PX811_RS03405 (695291) 695291..695686 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PX811_RS03410 (695819) 695819..697426 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
PX811_RS03415 (697564) 697564..699822 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T274097 WP_000415584.1 NZ_CP119404:694993-695289 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT274097 WP_000650107.1 NZ_CP119404:695291-695686 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References