Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 586295..587094 Replicon chromosome
Accession NZ_CP119404
Organism Escherichia coli strain MRE162 substr. UK

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag PX811_RS02865 Protein ID WP_000347273.1
Coordinates 586295..586759 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PX811_RS02870 Protein ID WP_001307405.1
Coordinates 586759..587094 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX811_RS02835 (581296) 581296..581730 - 435 WP_000948842.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PX811_RS02840 (581748) 581748..582626 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PX811_RS02845 (582616) 582616..583395 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
PX811_RS02850 (583406) 583406..583879 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
PX811_RS02855 (583902) 583902..585182 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
PX811_RS02860 (585431) 585431..586240 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PX811_RS02865 (586295) 586295..586759 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PX811_RS02870 (586759) 586759..587094 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PX811_RS02875 (587243) 587243..588814 - 1572 WP_001273753.1 galactarate dehydratase -
PX811_RS02880 (589189) 589189..590523 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PX811_RS02885 (590539) 590539..591309 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T274095 WP_000347273.1 NZ_CP119404:c586759-586295 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT274095 WP_001307405.1 NZ_CP119404:c587094-586759 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References