Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2517146..2517669 Replicon chromosome
Accession NZ_CP119344
Organism Staphylococcus aureus strain N29CSA11

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag P1A16_RS12525 Protein ID WP_000074043.1
Coordinates 2517146..2517412 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag P1A16_RS12530 Protein ID WP_000587618.1
Coordinates 2517412..2517669 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A16_RS12505 (P1A16_12505) 2512452..2513639 - 1188 WP_000026194.1 MFS transporter -
P1A16_RS12510 (P1A16_12510) 2514035..2514811 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
P1A16_RS12515 (P1A16_12515) 2514804..2515466 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
P1A16_RS12520 (P1A16_12520) 2515714..2516790 - 1077 WP_001076673.1 M42 family metallopeptidase -
P1A16_RS12525 (P1A16_12525) 2517146..2517412 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
P1A16_RS12530 (P1A16_12530) 2517412..2517669 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1A16_RS12535 (P1A16_12535) 2518028..2518483 + 456 WP_000732076.1 DUF1307 domain-containing protein -
P1A16_RS12540 (P1A16_12540) 2518651..2520228 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
P1A16_RS12545 (P1A16_12545) 2520423..2521172 + 750 WP_000072466.1 CPBP family lipoprotein N-acylation protein LnsB -
P1A16_RS12550 (P1A16_12550) 2521403..2522596 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T274021 WP_000074043.1 NZ_CP119344:c2517412-2517146 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT274021 WP_000587618.1 NZ_CP119344:c2517669-2517412 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References