Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2460191..2460708 Replicon chromosome
Accession NZ_CP119344
Organism Staphylococcus aureus strain N29CSA11

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag P1A16_RS12250 Protein ID WP_000113262.1
Coordinates 2460191..2460457 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag P1A16_RS12255 Protein ID WP_000584499.1
Coordinates 2460457..2460708 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A16_RS12220 (P1A16_12220) 2455616..2456152 - 537 WP_031585827.1 GNAT family N-acetyltransferase -
P1A16_RS12225 (P1A16_12225) 2456385..2457209 - 825 WP_000572040.1 formate/nitrite transporter family protein -
P1A16_RS12230 (P1A16_12230) 2457426..2457608 - 183 WP_000230294.1 hypothetical protein -
P1A16_RS12235 (P1A16_12235) 2457692..2458159 - 468 WP_000153344.1 SRPBCC domain-containing protein -
P1A16_RS12240 (P1A16_12240) 2458345..2459895 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
P1A16_RS12245 (P1A16_12245) 2460079..2460156 - 78 Protein_2367 hypothetical protein -
P1A16_RS12250 (P1A16_12250) 2460191..2460457 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
P1A16_RS12255 (P1A16_12255) 2460457..2460708 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1A16_RS12260 (P1A16_12260) 2460873..2460974 - 102 WP_031774922.1 hypothetical protein -
P1A16_RS12265 (P1A16_12265) 2460981..2461580 - 600 WP_000162813.1 DsbA family protein -
P1A16_RS12270 (P1A16_12270) 2461599..2461961 - 363 WP_000819843.1 DUF4467 domain-containing protein -
P1A16_RS12275 (P1A16_12275) 2462216..2463466 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
P1A16_RS12280 (P1A16_12280) 2463563..2464294 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
P1A16_RS12285 (P1A16_12285) 2464291..2465010 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T274019 WP_000113262.1 NZ_CP119344:c2460457-2460191 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT274019 WP_000584499.1 NZ_CP119344:c2460708-2460457 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References