Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2574285..2574808 Replicon chromosome
Accession NZ_CP119341
Organism Staphylococcus aureus strain N29CSA02

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag P1A17_RS12930 Protein ID WP_000074043.1
Coordinates 2574285..2574551 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag P1A17_RS12935 Protein ID WP_000587618.1
Coordinates 2574551..2574808 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A17_RS12910 (2569591) 2569591..2570778 - 1188 WP_000026194.1 MFS transporter -
P1A17_RS12915 (2571174) 2571174..2571950 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
P1A17_RS12920 (2571943) 2571943..2572605 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
P1A17_RS12925 (2572853) 2572853..2573929 - 1077 WP_001076673.1 M42 family metallopeptidase -
P1A17_RS12930 (2574285) 2574285..2574551 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
P1A17_RS12935 (2574551) 2574551..2574808 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1A17_RS12940 (2575167) 2575167..2575622 + 456 WP_000732076.1 DUF1307 domain-containing protein -
P1A17_RS12945 (2575790) 2575790..2577367 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
P1A17_RS12950 (2577562) 2577562..2578311 + 750 WP_000072466.1 CPBP family lipoprotein N-acylation protein LnsB -
P1A17_RS12955 (2578542) 2578542..2579735 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T274012 WP_000074043.1 NZ_CP119341:c2574551-2574285 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT274012 WP_000587618.1 NZ_CP119341:c2574808-2574551 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References