Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2517330..2517847 Replicon chromosome
Accession NZ_CP119341
Organism Staphylococcus aureus strain N29CSA02

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag P1A17_RS12655 Protein ID WP_000113262.1
Coordinates 2517330..2517596 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag P1A17_RS12660 Protein ID WP_000584499.1
Coordinates 2517596..2517847 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A17_RS12625 (2512755) 2512755..2513291 - 537 WP_031585827.1 GNAT family N-acetyltransferase -
P1A17_RS12630 (2513524) 2513524..2514348 - 825 WP_000572040.1 formate/nitrite transporter family protein -
P1A17_RS12635 (2514565) 2514565..2514747 - 183 WP_000230294.1 hypothetical protein -
P1A17_RS12640 (2514831) 2514831..2515298 - 468 WP_000153344.1 SRPBCC domain-containing protein -
P1A17_RS12645 (2515484) 2515484..2517034 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
P1A17_RS12650 (2517218) 2517218..2517295 - 78 Protein_2448 hypothetical protein -
P1A17_RS12655 (2517330) 2517330..2517596 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
P1A17_RS12660 (2517596) 2517596..2517847 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1A17_RS12665 (2518012) 2518012..2518113 - 102 WP_031774922.1 hypothetical protein -
P1A17_RS12670 (2518120) 2518120..2518719 - 600 WP_000162813.1 DsbA family protein -
P1A17_RS12675 (2518738) 2518738..2519100 - 363 WP_000819843.1 DUF4467 domain-containing protein -
P1A17_RS12680 (2519355) 2519355..2520605 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
P1A17_RS12685 (2520702) 2520702..2521433 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
P1A17_RS12690 (2521430) 2521430..2522149 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T274010 WP_000113262.1 NZ_CP119341:c2517596-2517330 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT274010 WP_000584499.1 NZ_CP119341:c2517847-2517596 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References