Detailed information of TA system TA274001

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2078824..2079299
• Replicon: chromosome
• Accession: NZ_CP119341
• Organism: Staphylococcus aureus strain N29CSA02

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: P1A17_RS10280
• Protein ID: WP_000387655.1
• Coordinates: 2078824..2079126 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2079175..2079299 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P1A17_RS10260	2074644..2075597	-	954	WP_000766912.1	ornithine cyclodeaminase family protein	-
P1A17_RS10265	2076095..2076196	-	102	Protein_1985	hypothetical protein	-
P1A17_RS10270	2076274..2077014	-	741	WP_000185611.1	type II CAAX endopeptidase family protein	-
P1A17_RS10275	2077359..2078813	-	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
P1A17_RS10280	2078824..2079126	-	303	WP_000387655.1	phage holin	Toxin
-	2079175..2079299	+	125	-	-	Antitoxin
P1A17_RS10290	2079324..2079431	-	108	WP_000253687.1	putative holin-like toxin	-
P1A17_RS10295	2079665..2079964	-	300	WP_000466781.1	DUF2951 family protein	-
P1A17_RS10300	2080010..2080174	-	165	WP_000916020.1	XkdX family protein	-
P1A17_RS10305	2080167..2080556	-	390	WP_001166602.1	DUF2977 domain-containing protein	-
P1A17_RS10310	2080556..2082022	-	1467	WP_000067150.1	BppU family phage baseplate upper protein	-
P1A17_RS10315	2082052..2083932	-	1881	WP_275600309.1	hypothetical protein	-
P1A17_RS10320	2083948..2084238	-	291	WP_000179860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2077359..2134708	57349

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T274001 WP_000387655.1 NZ_CP119341:c2079126-2078824 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

Antitoxin

Nucleotide

• Length: 125 bp

>AT274001 NZ_CP119341:2079175-2079299 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin