273997

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2547201..2547724 Replicon chromosome
Accession NZ_CP119340
Organism Staphylococcus aureus strain N28CSA05

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag P1A15_RS12685 Protein ID WP_000074043.1
Coordinates 2547201..2547467 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag P1A15_RS12690 Protein ID WP_000587618.1
Coordinates 2547467..2547724 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A15_RS12665 (P1A15_12665) 2542507..2543694 - 1188 WP_000026194.1 MFS transporter -
P1A15_RS12670 (P1A15_12670) 2544090..2544866 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
P1A15_RS12675 (P1A15_12675) 2544859..2545521 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
P1A15_RS12680 (P1A15_12680) 2545769..2546845 - 1077 WP_001076673.1 M42 family metallopeptidase -
P1A15_RS12685 (P1A15_12685) 2547201..2547467 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
P1A15_RS12690 (P1A15_12690) 2547467..2547724 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1A15_RS12695 (P1A15_12695) 2548083..2548538 + 456 WP_000732076.1 DUF1307 domain-containing protein -
P1A15_RS12700 (P1A15_12700) 2548706..2550283 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
P1A15_RS12705 (P1A15_12705) 2550478..2551227 + 750 WP_000072466.1 CPBP family lipoprotein N-acylation protein LnsB -
P1A15_RS12710 (P1A15_12710) 2551458..2552651 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T273997 WP_000074043.1 NZ_CP119340:c2547467-2547201 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp


Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT273997 WP_000587618.1 NZ_CP119340:c2547724-2547467 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB T1YCD0


Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References