Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2490247..2490764 Replicon chromosome
Accession NZ_CP119340
Organism Staphylococcus aureus strain N28CSA05

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag P1A15_RS12410 Protein ID WP_000113262.1
Coordinates 2490247..2490513 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag P1A15_RS12415 Protein ID WP_000584499.1
Coordinates 2490513..2490764 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A15_RS12380 (P1A15_12380) 2486150..2486332 - 183 WP_000230294.1 hypothetical protein -
P1A15_RS12385 (P1A15_12385) 2486416..2486883 - 468 WP_000153344.1 SRPBCC domain-containing protein -
P1A15_RS12390 (P1A15_12390) 2487069..2487575 - 507 Protein_2396 metal-binding protein ZinT -
P1A15_RS12395 (P1A15_12395) 2487676..2488848 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -
P1A15_RS12400 (P1A15_12400) 2488899..2489951 - 1053 Protein_2398 zinc ABC transporter substrate-binding protein -
P1A15_RS12405 (P1A15_12405) 2490135..2490212 - 78 Protein_2399 hypothetical protein -
P1A15_RS12410 (P1A15_12410) 2490247..2490513 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
P1A15_RS12415 (P1A15_12415) 2490513..2490764 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1A15_RS12420 (P1A15_12420) 2490929..2491030 - 102 WP_031774922.1 hypothetical protein -
P1A15_RS12425 (P1A15_12425) 2491037..2491636 - 600 WP_000162813.1 DsbA family protein -
P1A15_RS12430 (P1A15_12430) 2491655..2492017 - 363 WP_000819843.1 DUF4467 domain-containing protein -
P1A15_RS12435 (P1A15_12435) 2492272..2493521 + 1250 Protein_2405 FemA/FemB family glycyltransferase FmhA -
P1A15_RS12440 (P1A15_12440) 2493618..2494349 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
P1A15_RS12445 (P1A15_12445) 2494346..2495065 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2487676..2488848 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T273995 WP_000113262.1 NZ_CP119340:c2490513-2490247 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT273995 WP_000584499.1 NZ_CP119340:c2490764-2490513 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References