Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2542644..2543167 Replicon chromosome
Accession NZ_CP119338
Organism Staphylococcus aureus strain N09HSA11

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag P1A14_RS12660 Protein ID WP_000074043.1
Coordinates 2542644..2542910 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag P1A14_RS12665 Protein ID WP_000587618.1
Coordinates 2542910..2543167 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A14_RS12640 (P1A14_12640) 2537950..2539137 - 1188 WP_000026194.1 MFS transporter -
P1A14_RS12645 (P1A14_12645) 2539533..2540309 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
P1A14_RS12650 (P1A14_12650) 2540302..2540964 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
P1A14_RS12655 (P1A14_12655) 2541212..2542288 - 1077 WP_001076673.1 M42 family metallopeptidase -
P1A14_RS12660 (P1A14_12660) 2542644..2542910 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
P1A14_RS12665 (P1A14_12665) 2542910..2543167 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1A14_RS12670 (P1A14_12670) 2543526..2543981 + 456 WP_000732076.1 DUF1307 domain-containing protein -
P1A14_RS12675 (P1A14_12675) 2544149..2545726 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
P1A14_RS12680 (P1A14_12680) 2545921..2546670 + 750 WP_000072466.1 CPBP family lipoprotein N-acylation protein LnsB -
P1A14_RS12685 (P1A14_12685) 2546901..2548094 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T273988 WP_000074043.1 NZ_CP119338:c2542910-2542644 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT273988 WP_000587618.1 NZ_CP119338:c2543167-2542910 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References