Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2485747..2486264 Replicon chromosome
Accession NZ_CP119338
Organism Staphylococcus aureus strain N09HSA11

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag P1A14_RS12385 Protein ID WP_000113262.1
Coordinates 2485747..2486013 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag P1A14_RS12390 Protein ID WP_000584499.1
Coordinates 2486013..2486264 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1A14_RS12355 (P1A14_12355) 2481172..2481708 - 537 WP_031585827.1 GNAT family N-acetyltransferase -
P1A14_RS12360 (P1A14_12360) 2481941..2482765 - 825 WP_000572040.1 formate/nitrite transporter family protein -
P1A14_RS12365 (P1A14_12365) 2482982..2483164 - 183 WP_000230294.1 hypothetical protein -
P1A14_RS12370 (P1A14_12370) 2483248..2483715 - 468 WP_000153344.1 SRPBCC domain-containing protein -
P1A14_RS12375 (P1A14_12375) 2483901..2485451 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
P1A14_RS12380 (P1A14_12380) 2485635..2485712 - 78 Protein_2397 hypothetical protein -
P1A14_RS12385 (P1A14_12385) 2485747..2486013 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
P1A14_RS12390 (P1A14_12390) 2486013..2486264 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1A14_RS12395 (P1A14_12395) 2486429..2486530 - 102 WP_031774922.1 hypothetical protein -
P1A14_RS12400 (P1A14_12400) 2486537..2487136 - 600 WP_000162813.1 DsbA family protein -
P1A14_RS12405 (P1A14_12405) 2487155..2487517 - 363 WP_000819843.1 DUF4467 domain-containing protein -
P1A14_RS12410 (P1A14_12410) 2487772..2489022 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
P1A14_RS12415 (P1A14_12415) 2489119..2489850 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
P1A14_RS12420 (P1A14_12420) 2489847..2490566 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T273986 WP_000113262.1 NZ_CP119338:c2486013-2485747 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT273986 WP_000584499.1 NZ_CP119338:c2486264-2486013 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References