Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 119839..120484 Replicon plasmid unnamed1
Accession NZ_CP119336
Organism Vibrio alginolyticus strain 2-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PY250_RS23915 Protein ID WP_258520172.1
Coordinates 119839..120189 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PY250_RS23920 Protein ID WP_170897565.1
Coordinates 120179..120484 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY250_RS23870 (PY250_23870) 114966..115373 - 408 WP_004364961.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
PY250_RS23875 (PY250_23875) 115469..116365 + 897 WP_020744994.1 cation transporter -
PY250_RS23880 (PY250_23880) 116369..116473 + 105 Protein_122 signal peptidase II -
PY250_RS23885 (PY250_23885) 116485..116817 + 333 Protein_123 transposase -
PY250_RS23890 (PY250_23890) 116903..117430 + 528 WP_275593691.1 Spy/CpxP family protein refolding chaperone -
PY250_RS23895 (PY250_23895) 117441..117722 + 282 WP_105935177.1 SHOCT domain-containing protein -
PY250_RS23900 (PY250_23900) 117780..118169 + 390 WP_113606151.1 metalloregulator ArsR/SmtB family transcription factor -
PY250_RS23905 (PY250_23905) 118245..118394 + 150 WP_181714985.1 hypothetical protein -
PY250_RS23910 (PY250_23910) 118939..119565 - 627 WP_238777244.1 recombinase family protein -
PY250_RS23915 (PY250_23915) 119839..120189 + 351 WP_258520172.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PY250_RS23920 (PY250_23920) 120179..120484 + 306 WP_170897565.1 XRE family transcriptional regulator Antitoxin
PY250_RS23925 (PY250_23925) 120722..122194 - 1473 WP_275593694.1 group II intron reverse transcriptase/maturase -
PY250_RS23930 (PY250_23930) 122904..123004 + 101 Protein_132 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..237145 237145


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-90)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13475.31 Da        Isoelectric Point: 4.9860

>T273979 WP_258520172.1 NZ_CP119336:119839-120189 [Vibrio alginolyticus]
MWNVVTRPLFDEWFLSLDESDQINVRACIQVLLERGPQLSRPYADTVEDSKHSNMKELRVQSNGKPIRAFFAFDPERTGI
ILCGGDKTGDKRFYKKMIPIADAEFDEHLEELKNEK

Download         Length: 351 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10928.77 Da        Isoelectric Point: 8.5752

>AT273979 WP_170897565.1 NZ_CP119336:120179-120484 [Vibrio alginolyticus]
MKSNPLSVLDAKMSPEALAAAKEKAADMLLDIRLAELREITHLSQVEIAKAMGISQPSVANLEKSGKDLRLSSLKKYVEA
TGGKLRIDVELPDGKHFGFPV

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References