Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 278687..279462 Replicon chromosome
Accession NZ_CP119332
Organism Klebsiella pneumoniae strain CQ22WZ0036

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag OMP07_RS01465 Protein ID WP_004150910.1
Coordinates 278977..279462 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag OMP07_RS01460 Protein ID WP_004150912.1
Coordinates 278687..278980 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP07_RS01440 (OMP07_01440) 273895..274497 - 603 WP_062954968.1 short chain dehydrogenase -
OMP07_RS01445 (OMP07_01445) 274595..275506 + 912 WP_004188550.1 LysR family transcriptional regulator -
OMP07_RS01450 (OMP07_01450) 275507..276655 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
OMP07_RS01455 (OMP07_01455) 276666..278042 - 1377 WP_004217775.1 cystathionine beta-synthase -
OMP07_RS01460 (OMP07_01460) 278687..278980 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
OMP07_RS01465 (OMP07_01465) 278977..279462 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
OMP07_RS01470 (OMP07_01470) 280166..280759 + 594 WP_004188553.1 hypothetical protein -
OMP07_RS01475 (OMP07_01475) 280856..281072 + 217 Protein_290 transposase -
OMP07_RS01480 (OMP07_01480) 281678..282550 + 873 WP_004188557.1 ParA family protein -
OMP07_RS01485 (OMP07_01485) 282550..282933 + 384 WP_004150906.1 hypothetical protein -
OMP07_RS01490 (OMP07_01490) 282926..284293 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 280856..281008 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T273955 WP_004150910.1 NZ_CP119332:278977-279462 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT273955 WP_004150912.1 NZ_CP119332:278687-278980 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References