27395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1248891..1249113 Replicon chromosome
Accession NC_017638
Organism Escherichia coli DH1

Toxin (Protein)


Gene name ldrD Uniprot ID D3H2K1
Locus tag ECDH1ME8569_RS06175 Protein ID WP_000170955.1
Coordinates 1248891..1248998 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1249046..1249113 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECDH1ME8569_RS06145 (ECDH1ME8569_1151) 1244747..1245580 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
ECDH1ME8569_RS06150 (ECDH1ME8569_1152) 1245577..1245969 + 393 WP_000200374.1 invasion regulator SirB2 -
ECDH1ME8569_RS06155 (ECDH1ME8569_1153) 1245973..1246782 + 810 WP_001257044.1 invasion regulator SirB1 -
ECDH1ME8569_RS06160 (ECDH1ME8569_1154) 1246818..1247672 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
ECDH1ME8569_RS06165 (ECDH1ME8569_1155) 1247821..1247928 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
ECDH1ME8569_RS06170 (ECDH1ME8569_1156) 1248356..1248463 - 108 WP_000170963.1 small toxic polypeptide LdrB -
ECDH1ME8569_RS06175 (ECDH1ME8569_1157) 1248891..1248998 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC Toxin
- 1249046..1249113 + 68 - - Antitoxin
ECDH1ME8569_RS06180 (ECDH1ME8569_1158) 1249402..1250502 - 1101 WP_000063607.1 sodium-potassium/proton antiporter ChaA -
ECDH1ME8569_RS06185 (ECDH1ME8569_1159) 1250772..1251002 + 231 WP_001146444.1 putative cation transport regulator ChaB -
ECDH1ME8569_RS06190 (ECDH1ME8569_1160) 1251160..1251855 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
ECDH1ME8569_RS06195 (ECDH1ME8569_1161) 1251899..1252252 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
ECDH1ME8569_RS06200 (ECDH1ME8569_1162) 1252437..1253831 + 1395 WP_000086217.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4013.82 Da        Isoelectric Point: 11.4779

>T27395 WP_000170955.1 NC_017638:c1248998-1248891 [Escherichia coli DH1]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T27395 NC_017638:c1248998-1248891 [Escherichia coli DH1]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 68 bp

>AT27395 NC_017638:1249046-1249113 [Escherichia coli DH1]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J2A9

Antitoxin

Download structure file

References