273947

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3603529..3604179 Replicon chromosome
Accession NZ_CP119319
Organism MAG: Kluyvera intermedia isolate MAG 4159

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P0Y47_RS16455 Protein ID WP_279215769.1
Coordinates 3603529..3603870 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P0Y47_RS16460 Protein ID WP_279215770.1
Coordinates 3603880..3604179 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0Y47_RS16435 (3599815) 3599815..3601206 + 1392 WP_062776717.1 hexose-6-phosphate:phosphate antiporter -
P0Y47_RS16440 (3601345) 3601345..3602250 - 906 WP_279215766.1 LysR family transcriptional regulator -
P0Y47_RS16445 (3602356) 3602356..3602808 + 453 WP_062776721.1 DUF1198 family protein -
P0Y47_RS16450 (3602911) 3602911..3603435 + 525 WP_279215767.1 SRPBCC domain-containing protein -
P0Y47_RS16455 (3603529) 3603529..3603870 + 342 WP_279215769.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P0Y47_RS16460 (3603880) 3603880..3604179 + 300 WP_279215770.1 XRE family transcriptional regulator Antitoxin
P0Y47_RS16465 (3604285) 3604285..3605472 + 1188 WP_062776728.1 purine ribonucleoside efflux pump NepI -
P0Y47_RS16470 (3605583) 3605583..3606965 - 1383 WP_279215771.1 carbohydrate porin -
P0Y47_RS16475 (3607128) 3607128..3607427 - 300 WP_279215772.1 PTS lactose/cellobiose transporter subunit IIA -
P0Y47_RS16480 (3607512) 3607512..3608834 - 1323 WP_062776734.1 PTS transporter subunit EIIC -
P0Y47_RS16485 (3608848) 3608848..3609162 - 315 WP_279215773.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13059.95 Da        Isoelectric Point: 6.0764

>T273947 WP_279215769.1 NZ_CP119319:3603529-3603870 [Kluyvera intermedia]
MWDVETTDVFDMWFEVQTAALKEDMLAAMLILSEYGPQLGRPFADTVNGSTFSNMKELRIQHQGHPIRAFFVFDPARHGI
VLCAGDKTGFNEKRFYKDMIKLADAEYRKHLNQ

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10980.90 Da        Isoelectric Point: 9.7665

>AT273947 WP_279215770.1 NZ_CP119319:3603880-3604179 [Kluyvera intermedia]
MATLKELMAKQSPESQARITEKVEVMRQVIALNMLREELNLSQAEVAAAMGVKQPTIAKMEQADNDPRLSTLKRYVTALG
GELSMEVKLPTGKRVAFHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References