Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 572557..573217 Replicon chromosome
Accession NZ_CP119319
Organism MAG: Kluyvera intermedia isolate MAG 4159

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P0Y47_RS02405 Protein ID WP_279216392.1
Coordinates 572557..572910 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P0Y47_RS02410 Protein ID WP_062778255.1
Coordinates 572915..573217 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0Y47_RS02395 (569056) 569056..569487 + 432 WP_153742584.1 universal stress protein -
P0Y47_RS02400 (569535) 569535..572225 + 2691 WP_279216391.1 cation-transporting P-type ATPase -
P0Y47_RS02405 (572557) 572557..572910 + 354 WP_279216392.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P0Y47_RS02410 (572915) 572915..573217 + 303 WP_062778255.1 XRE family transcriptional regulator Antitoxin
P0Y47_RS02415 (573561) 573561..573923 + 363 WP_153742588.1 helix-turn-helix domain-containing protein -
P0Y47_RS02420 (574066) 574066..574851 - 786 WP_153742589.1 SDR family oxidoreductase -
P0Y47_RS02425 (574987) 574987..575472 - 486 WP_153742590.1 NAD(P)-binding domain-containing protein -
P0Y47_RS02430 (575561) 575561..577018 - 1458 WP_279216393.1 efflux transporter outer membrane subunit -
P0Y47_RS02435 (577108) 577108..577722 + 615 WP_013575227.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13268.08 Da        Isoelectric Point: 6.2818

>T273941 WP_279216392.1 NZ_CP119319:572557-572910 [Kluyvera intermedia]
VWTIKTTDGFDNWFSTLCATDRASVLASLLVLREKGPGLPRPYADTIKGSCYSNMKELRVQSQGDPIRVFFAFDPYRTGI
LLCAGNKVGNEKRFYNQMIAVADREFTDYLNTLDDKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.85 Da        Isoelectric Point: 5.1679

>AT273941 WP_062778255.1 NZ_CP119319:572915-573217 [Kluyvera intermedia]
MGRTLEQLLADEKPDVVADAQAMAADILLNIHLAELREKVQKTQVEMAEVLGIRQPTVASMEKPGRDMKLSTLKRYVEAT
GGKLRFDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References